Revisão sistemática: não há evidência de eficácia e segurança na associação da hidroxicloroquina com azitromicina para COVID-19

Crédito: Dercilio.

Uma revisão sistemática rápida (rapid review methodology), produzida por meio de uma ação colaborativa entre o Núcleos de Avaliação de Tecnologias em Saúde do Hospital Moinhos de Vento (NATS-HMV) e do Hospital Sírio-Libanês (NATS-HSL), e a Unidade de Avaliação de Tecnologias em Saúde do Hospital Alemão Oswaldo Cruz (UATS-HAOC), avaliou a eficácia da associação hidroxicloroquina/cloroquina com azitromicina para pacientes com COVID-19.

Contexto

Publicações recentes têm chamado a atenção para o possível benefício da associação hidroxicloroquina/cloroquina e azitromicina no tratamento de pacientes infectados pelo novo coronavírus (SARS-CoV-2).

Objetivos

Identificar, avaliar sistematicamente e sumarizar as melhores evidências científicas disponíveis sobre a eficácia e a segurança da associação hidroxicloroquina/cloroquina e azitromicina para COVID-19.

Métodos

Revisão sistemática rápida com buscas em 28 de abril de 2020.

Resultados

Após o processo de seleção, foram identificados 11 estudos e 13 protocolos de ensaios clínicos em andamento. O benefício documentado da associação hidroxicloroquina/cloroquina e azitromicina ainda é bastante limitado.

Conclusões

A revisão sistemática rápida identificou 11 ensaios clínicos com dados disponíveis e 13 protocolos registrados em andamento que se propõem a avaliar os efeitos da hidroxicloroquina/cloroquina associada a azitromicina no paciente com COVID-19. Até o momento, a eficácia e a segurança dessa intervenção para pacientes com infecção por SARS-CoV-2 ainda são consideradas incertas. Sugere-se cautela no uso dessa associação, pois pode haver um aumento do risco de complicações cardíacas.

Fonte

Referências

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